KPV 10mg

KPV (Lys-Pro-Val) is a C-terminal tripeptide of α-MSH that retains potent anti-inflammatory properties without hormonal melanocortin receptor activity. Primary mechanism: direct NF-κB inhibition at nanomolar concentrations. Recognised by the intestinal PepT1 transporter, enabling targeted uptake in inflamed gut epithelium.

• NF-κB pathway inhibition — blocks NF-κB nuclear translocation at nanomolar concentrations without systemic immunosuppression.
• Intestinal anti-inflammatory — PepT1-mediated uptake enables targeted delivery to inflamed intestinal tissue.
• Gut barrier restoration — repairs tight-junction proteins (claudin, occludin, ZO-1) in inflammatory models.
• Antimicrobial properties — significant inhibition of S. aureus and MRSA colony formation in wound models (2025 research).
• Complements BPC-157 — complementary anti-inflammatory and repair mechanisms for gastrointestinal research.

⚠️ For research use only. Not for human or animal consumption. Store at −20°C. Reconstitute with Bacteriostatic Water.